Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated From Centenarians in a SAMP8 Mouse Model
This inspiring anti-aging research conducted by Fang et al. studied the anti-aging effects of a probiotic combination isolated from Centenarians on a SAMP8 mouse model.
Population aging is a prominent global problem in today’s society. No good methods have yet been discovered to treat or prevent it.
In this research, they screened bacteria from centenarians then selected four probiotics to form a combination: Lactobacillus fermentum SX-0718, L. casei SX-1107, Bifidobacterium longum SX-1326, and B. animalis SX-0582. They evaluated the anti-aging effects of the probiotic combination, on senescence accelerated mouse prone 8 (SAMP8) model, through behavioural testing, neuroinflammation, intestinal inflammation, and intestinal microbiota
They were able to show that the probiotic combination:
- Improved the impaired spatial memory, motor dysfunction, and decreased exploratory behavior in aging mice.
- Inhibited Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NFκB)-induced neuroinflammation and up-regulated the expression of Sirt 1 to protect hippocampal neurons.
- Regulated the intestinal microbiota, reduced the relative abundance of Alistipesand Prevotella in SAMP8 mice, inhibited TLR4/NFκB-induced intestinal inflammation, and increased the expression of intestinal permeability related proteins zonula occludens-1 (ZO-1) and Occuldin.
In summary, the anti-aging effects of the probiotic combination may be through regulating intestinal microbiota and inhibiting TLR4/NFκB-induced inflammation.