Marvin Edeas

Prof. Marvin Edeas from Institut Cochin, INSERM U1016, Université de Paris, France, will attend the congress and discuss Decoding the Dialogue Between Mitochondria and Microbiota—A Key to Longevity.

Prof. Marvin Edeas will explore a groundbreaking concept in the biology of aging: the dynamic, bidirectional communication between mitochondria and the gut microbiota. These two complex systems—once studied independently—are now understood to form an integrated network that regulates metabolism, immunity, inflammation, and redox homeostasis.

Central to this dialogue are extracellular vesicles (EVs), exosomes, and microbial metabolites, which serve as molecular messengers enabling cross-talk between microbial communities and host mitochondria. This communication shapes cellular responses and systemic adaptation, and may influence the trajectory of aging itself.

Aging is not simply the accumulation of damage but may result from a breakdown in these inter-organellar and inter-kingdom communication pathways. Understanding how this dialogue is initiated, modulated, and disrupted with age could reveal a “code of longevity”—a set of biological signals that promote healthy aging and resilience against chronic disease.

Prof. Edeas will present conceptual frameworks and emerging evidence that position the mitochondria–microbiota axis as a central hub in longevity science. He will also discuss how decoding and modulating these molecular conversations could open new avenues for preventive and therapeutic strategies.

This presentation builds on themes developed in “Recent developments in mitochondrial medicine (part 2)”, published in 4open (2022), where these ideas are further elaborated in the context of mitochondrial medicine. Access the article