Mitochondrial Inhibitors Extend Lifespan in C. elegans

Doxycycline extends lifespan of C. elegans

A recent study led by Bonuccelli et al. at the University of Salford delves into the impact of mitochondrial inhibitors on aging, using the model organism C. elegans.

Key Findings:

  1. Mitochondrial Ribosome Inhibitors:

    • Doxycycline and azithromycin significantly increased C. elegans’ median lifespan.
    • Improved pharyngeal muscle function and reduced lipofuscin accumulation were observed.

  2. Energy Dynamics:

    • Treated worms exhibited reduced ATP consumption, suggesting lower energy expenditure.

  3. Mitochondrial Complex Inhibition:

    • DPI, inhibiting mitochondrial complex I and II, prolonged median lifespan.

  4. Vitamin C’s Contradiction:

    • Vitamin C did not extend lifespan and resulted in higher ATP levels, highlighting complex interactions.

In summary, mitochondrial inhibitors, especially those affecting ribosomes and complex I/II, show promise in extending C. elegans lifespan. These findings offer valuable insights into the intricate relationship between mitochondrial processes and aging.

Article DOI.

Photo Credits: Bonuccelli et al. Aging (Albany NY). 2023