HKDC1 Revealed to Protect Against Cellular Senescence
In a groundbreaking study, Cui et al. from Osaka University have identified HKDC1 (hexokinase domain containing 1) as a direct target gene of TFEB (Transcription factor EB), uncovering its pivotal role in maintaining the delicate balance between mitochondria and lysosomes. This discovery sheds light on the intricate mechanisms through which cellular senescence, aging, and various diseases can be influenced by the joint dysfunction of these organelles.
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- The study reveals that the TFEB–HKDC1 axis plays a crucial role in PINK1/Parkin-dependent mitophagy, primarily through PINK1 stabilization.
- HKDC1, in interaction with voltage-dependent anion channels (VDACs), proves vital for the repair of damaged lysosomes and the maintenance of mitochondria–lysosome contact.
- Significantly, the study underscores the importance of HKDC1 in counteracting cellular senescence by ensuring the homeostasis of both mitochondria and lysosomes.
New research reveals a crucial insight into how cells manage both mitochondria and lysosomes, paving the way for potential treatments against aging-related diseases. These findings open doors to strategies for maintaining cell health and delaying aging.